- SymMover
- Synthavision
- SYSTAT
- System Mechanic
- System Mechanic
- System Mechanic Free
- System Shield Antivirus and Antispyware
- System Surveillance Pro
- System Tray Cleaner
- Talk a Lot Spoken English Course
- Talk Designer Assistant
- Tame
- Tandy DeskMate
- Tandy Scripsit
- TaskOPad
- Taste
- Tasword
- Tazapay
- tcACCESS
- tcVISION
- TeamViewer
- TeamViewer Portable
- TeraCopy
- TestPartner
- TextEdit
- TextMaker
- TextMaker
- TextWrangler
- The Logo Creator
- The Matrix Screen Saver
- The Ringtone Maker
- The VIPRE Gateway SDK
- The Weather Channel Desktop
- TheHunter
- ThinkFree Office
- Thunderbird
- Time Matters
- Time tracker
- TimeLeft
- TimesOwn Pro
- Timeworks Publisher
- Titanium Maximum Security
- TMON
- Toolwiz Care
- Toon Boom Animate
- Toon Boom Harmony
- Toon Boom Harmony Stand Alone
- Toon Boom Manager
- Toon Boom Pencil Check Pro
- Toon Boom Storyboard
- Toon Boom Storyboard Pro
- Toon Boom Storyboard Pro 3D
- Toon Boom Studio
- Toon Gramps update
- TOPS-20
- TOS/360
- Total Spy
- Total Video Player
- TPF
- Traktor Pro
- Transaction Management eXecutive
- Trend Micro HijackThis
- Trend Micro Internet Security
- Tru64 UNIX
- Tru64 UNIX
- TSOS
- TSS/360
- Tube2File
- TuneUp Utilities
- TuneUp Utilities 2012
- Turbo Pascal
- Tweaks.com Logon Changer
- TweetDeck
- TypingMaster Pro Typing Tutor
- TypingMaster Typing Test
- Ulead GIF Animator
- Ultra MP4 Video Converter
- UltraEdit
- Ultraget Video Downloader Free
- UltraISO Premium
- Ultrix
- UMPlayer
- Undersea Adventure
- Unison Operating System
- UNIVAC EXEC 8
- UNIVAC EXEC I
- UNIVAC EXEC II
- Universal Barcode Font Advantage
- Universal Time-Sharing System
- UnixWare
- Unlocker
- Urchin Software
- USB Block
- USB Disk Security
- USB Lock
- USB Secure
- uTorrent
- Vcatcher
- vegaPort